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| choline transporter ： ウィキペディア英語版 |
choline transporter
The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the ''SLC5A7'' gene. It is a cell membrane transporter and carries choline into acetylcholine-synthesizing neurons.
Hemicholinium-3 is an inhibitor of the ChT and can be used to deplete acetylcholine stores, while coluracetam is an enhancer of the ChT and can increase cholinergic neurotransmission by enhancing acetylcholine synthesis.
==Function==
Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons.〔
Mutations in the ''SLC5A7'' gene have been associated with Distal spinal muscular atrophy with vocal cord paralysis (distal hereditary motor neuropathy type 7A).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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